8月10日(木)の16時より、TARAセミナーが開催されます。皆様お誘いあわせの上、是非ご参加ください。

日時:平成29年8月10日(木)16時00分~17時00分
会場:TARAセンターA棟2階セミナールーム[地図]
講師:峰尾 千恵子 准教授
  (テキサス大学サウスウエスタン医学センター小児科学)
演題:Role of Endothelial FcγRIIB and Hyposialylated IgG in Obesity-induced Insulin Resistance

要旨:Type 2 diabetes mellitus (T2DM) is a common complication of obesity; however, how obesity or high-fat diet (HFD) feeding contributes to development of systemic insulin resistance and ultimately T2DM is complex and not well understood. Our recent findings have revealed that IgG Fc domain is hyposialylated upon HFD feeding in mice, and that the hyposialylated IgG induces insulin resistance through activation of FcγRIIB in endothelium. We have made a parallel observation in human IgG isolated from T2DM patients. In the upcoming talk, I will summarize the newlydiscovered mechanisms that are operative both in obese mice and in T2DM in humans.