Welcome to Hiromi Yanagisawa Laboratory at TARA!

Cells constantly receive cues from extracellular environment and respond by changing cytoskeletal organization and cellular functions as well as initiating transcriptional program, thereby maintaining homeostasis. The extracellular environment is comprised of extracellular matrix (ECM), ECM degrading enzymes and cleaved products, growth factors/cytokines, and physical factors such as hypoxia, hyperoxia, and mechanical forces. Our laboratory aims to elucidate the tissue-specific and disease-specific extracellular environment, focusing on ECM in the blood vessel wall, to understand the interactions between cells and the environment and how those interactions impact cellular functions and behavior. We apply the obtained knowledge to understand the normal developmental process and mechanism of diseases and to develop new therapeutic strategies. We take biochemical, molecular, and genetic engineering approaches to achieve these goals.

Based on my own experience as a trainee and PI in the U.S. research institution for more than 20 years, I run our laboratory to train the independent researcher with 4Cs (Challenging, Creative, Consistent, and Collegial). He/she will be the one who can find the most exciting question and come up with a strategy to find the answer.

Just come and see our laboratory. You are always welcome!


Review paper published online

September 22nd, 2017

A review paper on thoracic aortic aneurysm written by Yoshito was published online on September 22 at the Journal of Atherosclerosis and Thrombosis website.

Access the paper from the link below: 
Y. Yamashiro and H. Yanagisawa: Crossing Bridges between Extra- and Intra-Cellular Events in Thoracic Aortic Aneurysms, J. Atheroscler. Thromb. (2017)

Activity Log (Hiromi)

September 22nd, 2017

Hiromi was elected as an International Fellow of the American Heart Association (FAHA) at the Council Meeting on Arteriosclerosis, Thrombosis and Vascular Biology held in Minneapolis on May 5th.

The photos from ATVB/PVD 2017 have been upload to the photo page.

Information on HBP Briefing Session

September 21st, 2017

Human Biology Program will host a briefing session to give the program publicity and call for applications.

Date and time: October 20, 17:00~18:00
Place: Room 105, Health and Medical Science Innovation Laboratory [Map] …[Read more]

>> News Archive

HBP Briefing Session
Fri., 10/20

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We are recruiting undergraduates seeking for a senior thesis project and graduate students (including rotation students). Our lab is open for a lab visit.
Student Recruitment